Preimplantation Genetic Diagnosis (PGD) is genetic testing on
embryos for chromosomal or genetic disorders thus allowing patients at risk for these disorders
to have their embryos tested before transfer during am in vitro fertilization (IVF) cycle.
PGD requires embryo biopsy and genetic analysis. Only the embryos that have the correct
number of number of chromosomes and are free from abnormalities are considered for transfer in
the IVF cycle. The genetic material of the embryo is not altered or harmed in any way during
PGD Testing. It is the study of chromosomal and genetic abnormalities in the embryo before its
transfer to the recipient mother.
Who should consider PGD?
PGD Services
"Preimplantation Genetic Diagnosis may not be available in all circumstances or for all genetic disorders"
PGD allows us to know which embryos are free from chromosomal anomalies and genetic
mutations. Its aims are to ensure healthy offspring and to stop the transmission of certain
pathologies.
The first step involves an exhaustive study of each case by our geneticists and molecular
biologists. Then a personalized diagnostic strategy for the future embryos is decided.
The couple must undergo an In Vitro fertilization (IVF) treatment. And microinjection (ICSI
technique) is advised in order to fertilize the oocytes.At this point embryo biopsy takes place; however, if the eight cell stage or blastocyst stage. Biopsy is not recommended as it reduces the viability of the embryo. The use of a micro laser only one cell is extracted (a blastomere), so that the future embryo is not damaged and that the implantation rate is not reduced, having already been reduced during the biopsy. At this point embryo biopsy takes place; however, if the six-eight division has not
been achieved, biopsy is not recommended as it reduces the viability of the embryo. Thanks to
the experience of our team and the use of a micro laser only one cell is extracted (a blastomere),
so that the future embryo is not damaged and that the implantation rate is not reduced, having
already been reduced during the biopsy.
The extracted blastomeres are analyzed in the Molecular Biology laboratory and the biopsied
embryos remain in culture until the genetic diagnosis has been achieved. The goal is to transfer
healthy and evolved embryos that will produce a totally normal pregnancy.